115-7C__Hsp70 Activator Silvestrol
Product Name
115-7C
Description
Hsp70 Activator
Purity
>98%
Molecular Formula
C23H22Cl2N2O5
Molecular Weight
477.34
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble in DMSO (20 mg/ml)
Source
Synthetic
Appearance
White Solid
SMILES
CC1=C(C(NC(=O)N1CCCC(=O)O)c2ccc(cc2Cl)Cl)C(=O)OCc3ccccc3
InChI
InChI=1S/C23H22Cl2N2O5/c1-14-20(22(30)32-13-15-6-3-2-4-7-15)21(17-10-9-16(24)12-18(17)25)26-23(31)27(14)11-5-8-19(28)29/h2-4,6-7,9-10,12,21H,5,8,11,13H2,1H3,(H,26,31)(H,28,29)
InChIKey
UHBVLBSCOSTTAV-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
115-7C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-123)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110134
Alternative Names
4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2
Research Areas
Cancer, Heat Shock
Scientific Background
115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
References
1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622.
2. Jinwal et al. (2009) J.Neurosci. 29:12079.
3. Chafekar et al. (2012) ACS Chem Biol. 7:1556.
4. Walter et al. (2011) J. Biol. Chem. 286:40486
Hsp70 Activator
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Jinwal et al. (2009) J.Neurosci. 29:12079.
3. Chafekar et al. (2012) ACS Chem Biol. 7:1556.
4. Walter et al. (2011) J. Biol. Chem. 286:40486