24(S)-Hydroxycholesterol__LXR ligand Exatecan (Mesylate)
Product Name
24(S)-Hydroxycholesterol
Description
LXR ligand
Purity
>98%
CAS No.
474-73-7
Molecular Formula
C27H46O2
Molecular Weight
402.7
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Ligand
Solubility
Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml – requires warming up to ~40°C).
Source
Synthetic
Appearance
White solid
SMILES
[C@]24([[email protected]function(t,e,r,n,c,a,p){try{t=document.currentScript||function(){for(t=document.getElementsByTagName(_script_),e=t.length;e–;)if(t[e].getAttribute(_data-cfhash_))return t[e]}();if(t&&(c=t.previousSibling)){p=t.parentNode;if(a=c.getAttribute(_data-cfemail_)){for(e=__,r=_0x_+a.substr(0,2)|0,n=2;a.length-n;n+=2)e+=_%_+(_0_+(_0x_+a.substr(n,2)^r).toString(16)).slice(-2);p.replaceChild(document.createTextNode(decodeURIComponent(e)),c)}p.removeChild(t)}}catch(u){}}()/* ]]> */]([C@@H]1CC=C3[C@@]([[email protected]function(t,e,r,n,c,a,p){try{t=document.currentScript||function(){for(t=document.getElementsByTagName(_script_),e=t.length;e–;)if(t[e].getAttribute(_data-cfhash_))return t[e]}();if(t&&(c=t.previousSibling)){p=t.parentNode;if(a=c.getAttribute(_data-cfemail_)){for(e=__,r=_0x_+a.substr(0,2)|0,n=2;a.length-n;n+=2)e+=_%_+(_0_+(_0x_+a.substr(n,2)^r).toString(16)).slice(-2);p.replaceChild(document.createTextNode(decodeURIComponent(e)),c)}p.removeChild(t)}}catch(u){}}()/* ]]> */]1CC2)(CC[[email protected]function(t,e,r,n,c,a,p){try{t=document.currentScript||function(){for(t=document.getElementsByTagName(_script_),e=t.length;e–;)if(t[e].getAttribute(_data-cfhash_))return t[e]}();if(t&&(c=t.previousSibling)){p=t.parentNode;if(a=c.getAttribute(_data-cfemail_)){for(e=__,r=_0x_+a.substr(0,2)|0,n=2;a.length-n;n+=2)e+=_%_+(_0_+(_0x_+a.substr(n,2)^r).toString(16)).slice(-2);p.replaceChild(document.createTextNode(decodeURIComponent(e)),c)}p.removeChild(t)}}catch(u){}}()/* ]]> */](O)C3)C)CC[C@@H]4[C@@H](CC[C@@H](C(C)C)O)C)C
InChI
InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChIKey
IOWMKBFJCNLRTC-XWXSNNQWSA-N
Safety Phrases
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Cite This Product
24(S)-Hydroxycholesterol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-384)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110395
Alternative Names
(3β,24S)-Cholest-5-ene-3,24-diol
Research Areas
Cell Signaling
PubChem ID
121948
Scientific Background
Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer’s disease and mild cognitive impairment.
References
1. Chawla A., et al. (2001) Science. 294(5548): 1866-70.
2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.
3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.
4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.
5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.
LXR ligand
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.
3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.
4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.
5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.