2-APB__TRP blocker PF-3084014
Product Name
2-APB
Description
TRP blocker
Purity
>98%
CAS No.
524-95-8
Molecular Formula
C14H16BNO
Molecular Weight
225.1
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Source
Synthetic
Appearance
White solid
SMILES
B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
InChI
InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKey
BLZVCIGGICSWIG-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Cite This Product
2-APB (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-316)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110265
Alternative Names
2-Aminoethoxydiphenylborane
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
1598
Scientific Background
2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
References
1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329
2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.
3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
TRP blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.
3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.