3-Methyladenine

3-Methyladenine__Autophagosome inhibitor EPZ015666

Product Name 3-Methyladenine
Description

Autophagosome inhibitor

Purity >98%
CAS No. 5142-23-4
Molecular Formula C6H7N5
Molecular Weight 149.2
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Source Synthetic
Appearance White solid.
SMILES C[N]2C1=NC=NC1=C(N=C2)N
InChI InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChIKey FSASIHFSFGAIJM-UHFFFAOYSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product 3-Methyladenine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-408)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19110405

Alternative Names 3-MA, 3-Methyl-3H-purin-6-amine
Research Areas Cancer, Autophagy
PubChem ID 1673
Scientific Background 3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
References 1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6.
2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.
3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.

3-Methyladenine

3-Methyladenine__Autophagosome inhibitor EPZ015666

Product Name 3-Methyladenine
Description

Autophagosome inhibitor

Purity >98%
CAS No. 5142-23-4
Molecular Formula C6H7N5
Molecular Weight 149.2
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Source Synthetic
Appearance White solid.
SMILES C[N]2C1=NC=NC1=C(N=C2)N
InChI InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChIKey FSASIHFSFGAIJM-UHFFFAOYSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product 3-Methyladenine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-408)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19110405

Alternative Names 3-MA, 3-Methyl-3H-purin-6-amine
Research Areas Cancer, Autophagy
PubChem ID 1673
Scientific Background 3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
References 1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6.
2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.
3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.