3-Methyladenine__Autophagosome inhibitor EPZ015666
Product Name
3-Methyladenine
Description
Autophagosome inhibitor
Purity
>98%
CAS No.
5142-23-4
Molecular Formula
C6H7N5
Molecular Weight
149.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Source
Synthetic
Appearance
White solid.
SMILES
C[N]2C1=NC=NC1=C(N=C2)N
InChI
InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChIKey
FSASIHFSFGAIJM-UHFFFAOYSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
3-Methyladenine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-408)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19110405
Alternative Names
3-MA, 3-Methyl-3H-purin-6-amine
Research Areas
Cancer, Autophagy
PubChem ID
1673
Scientific Background
3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
References
1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6.
2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.
3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.
Autophagosome inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.
3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.