AAL 993__VEGFR inhibitor ABT-199
Product Name
AAL 993
Description
VEGFR inhibitor
Purity
>98% (TLC)
CAS No.
269390-77-4
Molecular Formula
C20H16F3N3O
Molecular Weight
371.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml)
Source
Synthetic
Appearance
Pale yellow solid
SMILES
C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
InChI
InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
InChIKey
BLAFVGLBBOPRLP-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
AAL 993 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-424)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19111409
Alternative Names
2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors
PubChem ID
6398883
Scientific Background
AAL-993 is a very potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3, as well as PDGFR-β, c-Kit and CSF-1R at higher concentrations.
References
1. Manley P.W., et al. (2004) Biochimica Biophysica Acta. 1697(1-2): 17–27.
2. Ban H.S., Uno M., & Nakamura H. (2010) Cancer Letters. 296(1): 17–26.
VEGFR inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Ban H.S., Uno M., & Nakamura H. (2010) Cancer Letters. 296(1): 17–26.