AG490__JAK-2 kinase inhibitor LY2109761
Product Name
AG490
Description
JAK-2 kinase inhibitor
Purity
>98% (TLC)
CAS No.
133550-30-8
Molecular Formula
C17H14N2O3
Molecular Weight
294.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Source
Synthetic
Appearance
Tan solid
SMILES
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
InChI
InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKey
TUCIOBMMDDOEMM-RIYZIHGNSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 3), H301
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P391 Collect spillage.
P405 Store locked up.
Cite This Product
AG490 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-428)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19112123
Alternative Names
Tyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5328779
Scientific Background
AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
References
1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877.
2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828.
3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.
JAK-2 kinase inhibitor
Acute toxicity, Oral (Category 3), H301
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P391 Collect spillage.
P405 Store locked up.
2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828.
3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.