A 769662__AMPK kinase activator SHP099 (hydrochloride)
Product Name
A 769662
Description
AMPK kinase activator
Purity
>99% (HPLC)
CAS No.
844499-71-4
Molecular Formula
C20H12N2O3S
Molecular Weight
360.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Source
Synthetic
Appearance
Off-white solid
SMILES
C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
InChI
InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
InChIKey
CTESJDQKVOEUOY-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
A 769662 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-490)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19111160
Alternative Names
A-769662
Research Areas
Cell Signaling
PubChem ID
54708532
Scientific Background
A 769662 is a potent and reversible activator of AMP-activated protein kinase (AMPK). It has been shown to inhibit fatty acid synthesis and decreases plasma glucose and triglyceride levels in vivo.
References
1. Sanders M.J., et al. (2007) J. Biol. Chem. 282(45): 32539–32548.
2. Göransson O., et al. (2007) J. Biol. Chem. 282(45): 32549–32560.
AMPK kinase activator
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Göransson O., et al. (2007) J. Biol. Chem. 282(45): 32549–32560.