A-803467__NaV1.8 blocker RG7388
Product Name
A-803467
Description
NaV1.8 blocker
Purity
>98%
CAS No.
944261-79-4
Molecular Formula
C19H16ClNO4
Molecular Weight
357.79
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source
Synthetic
Appearance
Beige Solid
SMILES
COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC
InChI
InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChIKey
VHKBTPQDHDSBSP-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases: H3012
Cite This Product
A-803467 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-304)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19111223
Alternative Names
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
Research Areas
Ion Channels, Neuroscience, Sodium Channels
PubChem ID
16038374
Scientific Background
A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
References
1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.
NaV1.8 blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases: H3012