A-803467

A-803467__NaV1.8 blocker RG7388

Product Name A-803467
Description

NaV1.8 blocker

Purity >98%
CAS No. 944261-79-4
Molecular Formula C19H16ClNO4
Molecular Weight 357.79
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source Synthetic
Appearance Beige Solid
SMILES COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC
InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChIKey VHKBTPQDHDSBSP-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases: H3012
Cite This Product A-803467 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-304)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19111223

Alternative Names 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
Research Areas Ion Channels, Neuroscience, Sodium Channels
PubChem ID 16038374
Scientific Background A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
References 1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.

A-803467

A-803467__NaV1.8 blocker RG7388

Product Name A-803467
Description

NaV1.8 blocker

Purity >98%
CAS No. 944261-79-4
Molecular Formula C19H16ClNO4
Molecular Weight 357.79
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source Synthetic
Appearance Beige Solid
SMILES COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC
InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChIKey VHKBTPQDHDSBSP-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases: H3012
Cite This Product A-803467 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-304)

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19111223

Alternative Names 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
Research Areas Ion Channels, Neuroscience, Sodium Channels
PubChem ID 16038374
Scientific Background A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1).
References 1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195.