Amifostine__HIF-1α activator Baricitinib
Product Name
Amifostine
Description
HIF-1α activator
Purity
>98%
CAS No.
20537-88-6
Molecular Formula
C5H15N2O3PS
Molecular Weight
214.22
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble in water
Source
Synthetic
Appearance
White Solid
SMILES
C(CN)CNCCSP(=O)(O)O
InChI
InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChIKey
JKOQGQFVAUAYPM-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
Cite This Product
Amifostine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-210)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19113923
Alternative Names
S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate
Research Areas
Cancer, Apoptosis
PubChem ID
2141
Scientific Background
Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents (1, 2). Other effects include accelerated DNA repair (1), induction of cellular hypoxia (1), inhibition of apoptosis (2), alteration of gene expression (2) and modification of enzyme activity (2).
References
1. Kouvaris J.R., Kouloulias V.E., Blahos L.J. (2007) Oncologist. 12(6): 738-747.
2. Amifostine: BC Cancer Agency. 2006-03-01.
HIF-1α activator
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
2. Amifostine: BC Cancer Agency. 2006-03-01.