Amiodarone Hydrochloride__Autophagy inducer FRAX597
Product Name
Amiodarone Hydrochloride
Description
Autophagy inducer
Purity
>99%
CAS No.
19774-82-4
Molecular Formula
C25H29I2NO3•HCl
Molecular Weight
681.77
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 50 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
[H+].C1=CC=CC2=C1C(=C(O2)CCCC)C(=O)C3=CC(=C(OCCN(CC)CC)C(=C3)I)I.[Cl-]
InChI
InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChIKey
ITPDYQOUSLNIHG-UHFFFAOYSA-N
Safety Phrases
Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H303- May be harmful if swallowed.
H312 + H332- Harmful in contact with skin or if inhaled
Precautionary statements:
P280- Wear protective gloves/ protective clothing.
Cite This Product
Amiodarone Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-393)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114037
Alternative Names
2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Research Areas
Cancer, Autophagy
PubChem ID
441325
Scientific Background
Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
References
1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53.
2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H303- May be harmful if swallowed.
H312 + H332- Harmful in contact with skin or if inhaled
Precautionary statements:
P280- Wear protective gloves/ protective clothing.
2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.