Amlodipine

Amlodipine__L-type Ca channel blocker LY2606368 (dihydrochloride)

Product Name	Amlodipine
Description	L-type Ca channel blocker
Purity	>98%
CAS No.	111470-99-6
Molecular Formula	C20H25ClN2O5•C6H5SO3H
Molecular Weight	567.05

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO and to 10 mM in water
Source	Synthetic
Appearance	White Solid
SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
InChI	InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11
InChIKey	HTIQEAQVCYTUBX-UHFFFAOYSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R22 – Harmful if swallowed R62 – Possible risk of impaired fertility Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
Cite This Product	Amlodipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-315)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114084

Alternative Names	3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate, Norvasc
Research Areas	Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID	2162
Scientific Background	Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure.
References	1. Luksa J., Josic D., Kremser M., Kopitar Z and Milutinovic S. (1997) J Chromatorgraphy. B, Biomed Sci and App. 693(2): 367-375. 2. Bahl V.K., Jadhav U.M., Thacker H.P. (2009) Am J Cardiovasc Drugs. 9(3): 135-142.