Andrographolide

Andrographolide__Apoptosis Inducer Canagliflozin

Product Name	Andrographolide
Description	Apoptosis Inducer
Purity	>98%
CAS No.	5508-58-7
Molecular Formula	C20H30O5
Molecular Weight	350.45

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	DMSO
Source	Synthetic
Appearance	Off-white Solid
SMILES	OC3COC(=O)C3=CC[C@@H]1C(=C)CC[C@@H]2C(C)(CO)[[email protected]](O)CC[C@@]12C
InChI	InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6
InChIKey	BOJKULTULYSRAS-OTESTREVSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	Andrographolide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-220)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114223

Alternative Names	(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
Research Areas	Cancer, Apoptosis
PubChem ID	5318517
Scientific Background	Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement (2, 3).
References	1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158.