Anisomycin

Anisomycin__p38 MAP kinase activator SU5416

Product Name	Anisomycin
Description	p38 MAP kinase activator
Purity	>98%
CAS No.	22862-76-6
Molecular Formula	C14H19NO4
Molecular Weight	265.31

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Activator
Solubility	Soluble to 100 mM in DMSO and to 100 mM in ethanol
Source	Synthetic
Appearance	White solid
SMILES	CC(=O)O[[email protected]]1[C@@H](CN[[email protected]]1CC2=CC=C(C=C2)OC)O
InChI	InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
InChIKey	YKJYKKNCCRKFSL-BFHYXJOUSA-N
Safety Phrases	Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 – Toxic by inhilation, in contact with skin and if swallowed Hazard Phrases: H301 Precautionary Phrases: P301 + P310
Cite This Product	Anisomycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-266)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114224

Alternative Names	(2S,3R,4R)-4-Hydroxy-2-(4-methoxybenzyl)-3-pyrrolidinyl acetate
Research Areas	Cancer, Apoptosis
PubChem ID	253602
Scientific Background	Anisomycin is an antibiotic which inhibits protein synthesis (1). It interferes with protein and DNA synthesis by inhibiting peptidyl transferace on the 80S ribosome system. It can activate stress-activated protein kinases, MAPkinase and other signal transduction pathways.
References	1. Grollman A.P. (1967) J Biol Chem. 242(13): 3226-3233.