Antibiotic A-23187__Ca2+ ionophore AZD6738
Product Name
Antibiotic A-23187
Description
Ca2+ ionophore
Purity
>98%
CAS No.
52665-69-7
Molecular Formula
C29H37N3O6
Molecular Weight
523.63
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
C[[email protected]]1CCC2([C@@H](C[[email protected]]([[email protected]](O2)C(C)C(=O)C3=CC=CN3)C)C)O[[email protected]]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChI
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8
InChIKey
HIYAVKIYRIFSCZ-CVXKHCKVSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Antibiotic A-23187 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-227)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114657
Alternative Names
5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid, A23187, Calcimycin
Research Areas
Cancer, Apoptosis
PubChem ID
40486
Scientific Background
A23187 is a mobile ion-carrier that forms stable complexes with divalent cations. It has antibiotic properties against gram positive bacteria and funghi. It also acts as divalent cation ionophore, that is used to increase intracellular calcium levels in intact cells (1). It also induces apoptosis in some cells and prevents it in others (2).
References
1. Abbott B.J., et al. (1979) Antimicrob Agents Chemother. 16(6): 808-812.
2. http://a23187.4mg.com
Ca2+ ionophore
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. http://a23187.4mg.com