Apigenin__Protein kinase inhibitor Topotecan (Hydrochloride)
Product Name
Apigenin
Description
Protein kinase inhibitor
Purity
>98%
CAS No.
520-36-5
Molecular Formula
C15H10O5
Molecular Weight
270.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 50 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI
InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChIKey
KZNIFHPLKGYRTM-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68 – Possible risk of irreversible effects
Cite This Product
Apigenin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-249)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19114688
Alternative Names
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID
5280443
Scientific Background
Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).
References
1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11.
2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634.
3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
Protein kinase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68 – Possible risk of irreversible effects
2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634.
3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.