BAY 11 7082__IKK kinase inhibitor CC-930
Product Name
BAY 11 7082
Description
IKK kinase inhibitor
Purity
>98% (HPLC)
CAS No.
19542-67-7
Molecular Formula
C10H9NO2S
Molecular Weight
207.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
C1=C(S(=O)(=O)C=CC#N)C=CC(=C1)C
InChI
InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChIKey
DOEWDSDBFRHVAP-KRXBUXKQSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
BAY 11 7082 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-434)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116134
Alternative Names
Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5353431
Scientific Background
BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
References
1. Mori N., et al. (2002) Blood 100(5): 1828–1834.
2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
IKK kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.