BCTC__TRPV1 blocker AVE 0991 (sodium salt)
Product Name
BCTC
Description
TRPV1 blocker
Purity
>98%
CAS No.
393514-24-4
Molecular Formula
C20H25ClN4O
Molecular Weight
372.89
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO and to 40 mM in ethanol
Source
Synthetic
Appearance
White Solid
SMILES
CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
InChI
InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
InChIKey
ROGUAPYLUCHQGK-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
BCTC (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-307)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116245
Alternative Names
4-(3-Chloro-2-pyridinyl)-N-4-(2-methyl-2-propanyl)phenyl-1-piperazinecarboxamide
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
9929425
Scientific Background
BCTC is an inhibitor of capsaicin- and acid-mediated currents at rat VR1. Thus it has effects on acute, inflammatory and neuropathic pain in rats (1, 2).
References
1. Pomonis J.D., et al. (2003) J Pharmacol Exp Ther. 306(1): 387-393.
2. Valenzano K.J., et al. (2003) J Pharmacol Exp. Ther. 306(1): 377-386.
TRPV1 blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Valenzano K.J., et al. (2003) J Pharmacol Exp. Ther. 306(1): 377-386.