BIBW 2992__EGFR, HER2 kinase inhibitor EMD638683
Product Name
BIBW 2992
Description
EGFR, HER2 kinase inhibitor
Purity
>99%
CAS No.
850140-72-6
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
Source
Synthetic
Appearance
Crystalline solid
SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)Oemail protected4CCOC4
InChI
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Safety Phrases
Classification:
Acute Toxicity: Oral, Category 2
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1
Toxic To Reproduction, Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300: Fatal if swallowed.
H315: Causes skin irritation.
H318: Causes serious eye damage.
H361: Suspected of damaging fertility or the unborn child.
H373: May cause damage through prolonged or repeated exposure.
Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a {POISON CENTER/doctor/…}.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P314: Get medical attentiodvice if you feel unwell.
Cite This Product
BIBW 2992 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-496)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116382
Alternative Names
Afatinib, N-4-(3-chloro-4-fluorophenyl)amino-7-(3S)-tetrahydro-3-furanyloxy-6-quinazolinyl-4-(dimethylamino)-2-butenamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
10184653
Scientific Background
BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.
References
1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.
EGFR, HER2 kinase inhibitor
Acute Toxicity: Oral, Category 2
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1
Toxic To Reproduction, Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300: Fatal if swallowed.
H315: Causes skin irritation.
H318: Causes serious eye damage.
H361: Suspected of damaging fertility or the unborn child.
H373: May cause damage through prolonged or repeated exposure.
Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
P362+364: Take off contaminated clothing and wash it before reuse.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs, get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a {POISON CENTER/doctor/…}.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P314: Get medical attentiodvice if you feel unwell.