BIX-01294

BIX-01294__HMT inhibitor GSK2606414

Product Name	BIX-01294
Description	HMT inhibitor
Purity	>98%
CAS No.	935693-62-2
Molecular Formula	C28H38N6O2*3HCl
Molecular Weight	600.02

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (100 mM) or Water (100 mM)
Source	Synthetic
Appearance	Cream solid
SMILES	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl
InChI	InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
InChIKey	OSXFATOLZGZLSK-UHFFFAOYSA-N
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	BIX-01294 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-347)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116501

Alternative Names	2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-1-(phenylmethyl)-4-piperidinyl-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
Research Areas	Cancer, Cell Signaling, Epigenetics
PubChem ID	25150857
Scientific Background	G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
References	1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.