BML 277__CHK2 kinase inhibitor GKT137831
Product Name
BML 277
Description
CHK2 kinase inhibitor
Purity
>98% (TLC)
CAS No.
516480-79-8
Molecular Formula
C20H14ClN3O2
Molecular Weight
363.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml)
Source
Synthetic
Appearance
Off-white solid
SMILES
C1=CC(=CC=C1C2=NC3=C(N2)C=CC(=C3)C(=O)N)OC4=CC=C(C=C4)Cl
InChI
InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChIKey
UXGJAOIJSROTTN-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Bml 277 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-436)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116604
Alternative Names
Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
9969021
Scientific Background
Bml 277 is a highly selective inhibitor of Chk2, making it a useful tool for dissecting the role of Chk2 in cellular signaling.
References
1. Pereg Y., et al. (2006) Mol. Cell Biol. 26(18): 6819–6831.
CHK2 kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.