BML-278 SIRT1 activator__SIRT1 activator PSI-7977
Product Name
BML-278 SIRT1 activator
Description
SIRT1 activator
Purity
>98% (TLC); NMR (Conforms)
Molecular Formula
C24H25NO4
Molecular Weight
391.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 5 mg/ml DMSO
Source
Synthetic
Appearance
Off-White Solid
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Bml-278 SIRT1 activator (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-349)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116652
Alternative Names
N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Research Areas
Cell Signaling, Epigenetics
Scientific Background
A structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.
References
1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.
SIRT1 activator
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes