BRL-50481__PDE7 inhibitor Tonabersat
Product Name
BRL-50481
Description
PDE7 inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
433695-36-4
Molecular Formula
C9H12N2O4S
Molecular Weight
244.26
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
Source
Synthetic
Appearance
Cream solid
SMILES
CC1=C(C=C(C=C1)N+(=O)O-)S(=O)(=O)N(C)C
InChI
InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChIKey
IFIUFCJFLGCQPH-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
BRL-50481 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-374)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116762
Alternative Names
N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Research Areas
Neuroscience
PubChem ID
2921148
Scientific Background
BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
References
1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89.
2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.
PDE7 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.