Bafilomycin A1__Autophagy inhibitor Abiraterone (acetate)
Product Name
Bafilomycin A1
Description
Autophagy inhibitor
Purity
>95%
CAS No.
88899-55-2
Molecular Formula
C35H58O9
Molecular Weight
622.84
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 100% ethanol, methanol or DMSO.
Source
Synthetic
Appearance
White powder to colorless film.
SMILES
C@1(OC@@H(email protected(email protected(O)C1)C)C(C)C)(O)email protected(email protected(O)C@@H(email protected2OC(=O)C(=C/C(=C/email protected(C@@H(O)email protected(CC(=C/C=C/C@@H2OC)
InChI
InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H
InChIKey
XDHNQDDQEHDUTM-JQWOJBOSSA-N
Safety Phrases
Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315- Causes skin irritation.
H319- Causes serious eye irritation.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash skin thoroughly after handling.
P271- Use only outdoors or in a well-ventilated area.
P280- Wear protective gloves/ eye protection/ face protection.
P302 + P352- IF ON SKIN: Wash with plenty of soap and water.
P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312- Call a POISON CENTER or doctor/ physician if you feel unwell.
P321- Specific treatment (see supplemental first aid instructions on this label).
P332 + P313- If skin irritation occurs: Get medical advice/ attention.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P362- Take off contaminated clothing and wash before reuse.
P403 + P233- Store in a well-ventilated place. Keep container tightly closed.
P405- Store locked up.
P501- Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
Bafilomycin A1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-391)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1911608
Alternative Names
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-(1S,2R,3S)-2-hydroxy-1-methyl-3-(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-ylbutyl-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Research Areas
Cancer, Autophagy
PubChem ID
6436223
Scientific Background
Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.
References
1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212.
2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.
3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315- Causes skin irritation.
H319- Causes serious eye irritation.
H335- May cause respiratory irritation.
Precautionary statements:
P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264- Wash skin thoroughly after handling.
P271- Use only outdoors or in a well-ventilated area.
P280- Wear protective gloves/ eye protection/ face protection.
P302 + P352- IF ON SKIN: Wash with plenty of soap and water.
P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312- Call a POISON CENTER or doctor/ physician if you feel unwell.
P321- Specific treatment (see supplemental first aid instructions on this label).
P332 + P313- If skin irritation occurs: Get medical advice/ attention.
P337 + P313- If eye irritation persists: Get medical advice/ attention.
P362- Take off contaminated clothing and wash before reuse.
P403 + P233- Store in a well-ventilated place. Keep container tightly closed.
P405- Store locked up.
P501- Dispose of contents/ container to an approved waste disposal plant.
2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.
3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.