Bortezomib

Bortezomib__Proteasome inhibitor Erdafitinib

Product Name	Bortezomib
Description	Proteasome inhibitor
Purity	>98%
CAS No.	179324-69-7
Molecular Formula	C19H25BN4O4
Molecular Weight	384.2

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 50 mg/ml DMSO, 35 mg/ml Ethanol
Source	Synthetic
Appearance	White Powder
SMILES	B(email protected(CC(C)C)NC(=O)email protected(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
InChI	InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKey	GXJABQQUPOEUTA-RDJZCZTQSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116677

Alternative Names	B-(1R)-3-Methyl-1-(2S)-1-oxo-3-phenyl-2-(2-pyrazinylcarbonyl)aminopropylaminobutylboronic Acid; (1R)-3-Methyl-1-(2S)-1-oxo-3-phenyl-2-(pyrazinylcarbonyl)aminopropylaminobutylboronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade
Research Areas	Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID	387447
Scientific Background	Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.
References	1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.