Brefeldin A__GEF inhibitor LDN193189
Product Name
Brefeldin A
Description
GEF inhibitor
Purity
>98%
CAS No.
20350-15-6
Molecular Formula
C16H24O4
Molecular Weight
280.36
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source
Synthetic
Appearance
White Crystalline Solid
SMILES
Cemail protected1CCC/C=C/C@@H2CC@@H(Cemail protected2C@@H(/C=C/C(=O)O1)O)O
InChI
InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,
InChIKey
KQNZDYYTLMIZCT-PNFJWZTBSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68- Possible risk of irreversible effects
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product
Brefeldin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-225)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116730
Alternative Names
Cyanaein
Research Areas
Cancer, Apoptosis
PubChem ID
5287620
Scientific Background
Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
References
1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080.
2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.
GEF inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68- Possible risk of irreversible effects
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.