C16__PKR kinase inhibitor GDC-0834
Product Name
C16
Description
PKR kinase inhibitor
Purity
>98% (HPLC)
CAS No.
608512-97-6
Molecular Formula
C13H8N4OS
Molecular Weight
268.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO 12 mg/ml
Source
Synthetic
Appearance
Solid
SMILES
C1=CC2=C(C3=C1NC(=O)/C3=CC4=CNC=N4)SC=N2
InChI
InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3+
InChIKey
VFBGXTUGODTSPK-FPYGCLRLSA-N
Safety Phrases
Classification:
Chronic aquatic toxicity (Category 4), H413
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H413 May cause long lasting harmful effects to aquatic life.
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product
C16 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-498)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117058
Alternative Names
Imidazolo-oxindole PKR inhibitor C16, 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo2,3-gbenzothiazol-7-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
67016828
Scientific Background
C16 is a derivative of imidazolo-oxindole and inhibits RNA-dependent protein kinases (PKR). Its inhibition effect on PKR is ATP-binding site directed. C16 has been shown to specifically inhibit the apoptotic PKR/eIF2a signaling pathway.
References
1. Couturier J., et al. (2010) J. Biol. Chem. 285(2): 1272–1282.
2. Jammi N.V., Whitby L.R., & Beal P.A. (2003) Biochem. Biophys.Res. Comm. 308(1):50–57.
PKR kinase inhibitor
Chronic aquatic toxicity (Category 4), H413
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H413 May cause long lasting harmful effects to aquatic life.
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/ container to an approved waste disposal plant.
2. Jammi N.V., Whitby L.R., & Beal P.A. (2003) Biochem. Biophys.Res. Comm. 308(1):50–57.