CAPE

CAPE__NFkB Inhibitor Mdivi-1

Product Name	CAPE
Description	NFkB Inhibitor
Purity	>98%
CAS No.	104594-70-9
Molecular Formula	C17H16O4
Molecular Weight	284.31

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO, acetone, ethanol, methanol, acetonitrile
Source	Synthetic
Appearance	Off-White Solid
SMILES	C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O
InChI	InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
InChIKey	SWUARLUWKZWEBQ-VQHVLOKHSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
Cite This Product	CAPE (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-263)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117870

Alternative Names	2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate, Caffeic acid phenethyl ester
Research Areas	Cancer, Apoptosis
PubChem ID	5281787
Scientific Background	CAPE , an active component of propolis from honeybee hives is known to have antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral properties (1). It specifically inhibits NF-κB activation and inhibits the growth of transformed cells (1). Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
References	1. Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. (1996) Proc Natl Acad Sci USA. 93(17): 9090-9095.