CAPE__NFkB Inhibitor Mdivi-1
Product Name
CAPE
Description
NFkB Inhibitor
Purity
>98%
CAS No.
104594-70-9
Molecular Formula
C17H16O4
Molecular Weight
284.31
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO, acetone, ethanol, methanol, acetonitrile
Source
Synthetic
Appearance
Off-White Solid
SMILES
C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O
InChI
InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
InChIKey
SWUARLUWKZWEBQ-VQHVLOKHSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product
CAPE (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-263)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117870
Alternative Names
2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate, Caffeic acid phenethyl ester
Research Areas
Cancer, Apoptosis
PubChem ID
5281787
Scientific Background
CAPE , an active component of propolis from honeybee hives is known to have antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral properties (1). It specifically inhibits NF-κB activation and inhibits the growth of transformed cells (1). Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
References
1. Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. (1996) Proc Natl Acad Sci USA. 93(17): 9090-9095.
NFkB Inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338