CCT196969

CCT196969__RAF Inhibitor VE-822

Product Name	CCT196969
Description	RAF Inhibitor
Purity	96%
CAS No.	1163719-56-9
Molecular Formula	C27H24FN7O3
Molecular Weight	513.53

Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Product Type	Inhibitor
Solubility	Soluble in DMSO
Source	Synthetic
Appearance	White Solid
SMILES	CC(C)C)C1=NN(C2=CC=CC=C2)C(NC(NC(C(F)=C3)=CC=C3OC4=C5C(NC(C=N5)=O)=NC=C4)=O)=C1
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	CCT196969 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-185)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19118071

Alternative Names	1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido2,3-bpyrazin-8-yl)oxy)phenyl)urea, CCT-196969, CCT 196969
Research Areas	Cancer, Apoptosis
Scientific Background	CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
References	1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.