CZC 54252 Hydrochloride__LRRK2 inhibitor Firategrast
Product Name
CZC 54252 Hydrochloride
Description
LRRK2 inhibitor
Purity
>98%
CAS No.
1191911-27-9, 1330003-04-7
Molecular Formula
C22H26Cl2N6O4S
Molecular Weight
541.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
Yellow solid
SMILES
COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
InChI
InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChIKey
KWCBHUPLQMUKAF-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
CZC 54252 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-439)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120115
Alternative Names
N-{2-(5-Chloro-2-{2-methoxy-4-(4-morpholinyl)phenylamino}-4-pyrimidinyl)aminophenyl}methanesulfonamide hydrochloride
Research Areas
Cell Signaling
Scientific Background
CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
References
1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.
LRRK2 inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.