C-646__HAT inhibitor AZD3965
Product Name
C-646
Description
HAT inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
328968-36-1
Molecular Formula
C24H19N3O6
Molecular Weight
445.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 10 mg/ml DMSO
Source
Synthetic
Appearance
Orange Solid
SMILES
CC1=CC(=C(C=C1C)N+(=O)O-)C2=CC=C(O2)/C=C/3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C
InChI
InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+
InChIKey
HEKJYZZSCQBJGB-XDHOZWIPSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
C-646 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-350)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19116992
Alternative Names
4-4-5-(4,5-Dimethyl-2-nitrophenyl)-2-furanylmethylene-
4,5-dihydro-3-methyl-5-oxo-1Hpyrazol-
1-ylbenzoic acid
Research Areas
Cell Signaling, Epigenetics
PubChem ID
1285940
Scientific Background
Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
References
1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471.
2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.
3. Marek R., et al. (2011) J. Neurosci. 31: 7486.
4. Min S.W., et al. (2010) Neuron 67: 953.
HAT inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
4,5-dihydro-3-methyl-5-oxo-1Hpyrazol-
1-ylbenzoic acid
2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.
3. Marek R., et al. (2011) J. Neurosci. 31: 7486.
4. Min S.W., et al. (2010) Neuron 67: 953.