Camptothecin__Topoisomerase I inhibitor Resiquimod
Product Name
Camptothecin
Description
Topoisomerase I inhibitor
Purity
>98%
CAS No.
04-03-89
Molecular Formula
C20H16N2O4
Molecular Weight
348.36
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 5 mM in DMSO
Source
Synthetic
Appearance
Yellow solid
SMILES
CCC@@1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
InChI
InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1
InChIKey
VSJKWCGYPAHWDS-FQEVSTJZSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed
R46 – May cause heritable genetic damage
Hazard Phrases:
H302
Cite This Product
Camptothecin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-242)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117850
Alternative Names
(4S)-4-Ethyl-4-hydroxy-1H-pyrano3',4':6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione
Research Areas
Cancer, Apoptosis
PubChem ID
24360
Scientific Background
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
References
1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154.
2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.
3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.
Topoisomerase I inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed
R46 – May cause heritable genetic damage
Hazard Phrases:
H302
2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.
3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.