Capsaicin__TRPV1opener Dolutegravir
Product Name
Capsaicin
Description
TRPV1opener
Purity
>98%
CAS No.
404-86-4
Molecular Formula
C18H27NO3
Molecular Weight
305.41
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 100% ethanol, methanol or chloroform; Sparingly soluble in water
Source
Synthetic
Appearance
Off-White Solid
SMILES
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R25-37/38-41-42/43
Hazard Phrases:
H301-H311-H315-H317-H318-H334-H335
Precautionary Phrases:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Cite This Product
Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117907
Alternative Names
(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
Research Areas
Ion Channels, Neuroscience, Transient Receptor Potential Channels
PubChem ID
1548943
Scientific Background
Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
References
1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824.
2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.
TRPV1opener
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R25-37/38-41-42/43
Hazard Phrases:
H301-H311-H315-H317-H318-H334-H335
Precautionary Phrases:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.