Carfilzomib__20S Proteasome inhibitor CB-5083
Product Name
Carfilzomib
Description
20S Proteasome inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
868540-17-4
Molecular Formula
C40H57N5O7
Molecular Weight
719.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml)
Source
Synthetic
Appearance
White powder
SMILES
O=C(C@1(C)OC1)email protected(CC(C)C)NC(C@@H(NC(C@@H(NC(email protected(CCC2=CC=CC=C2)NC(CN3CCOCC3)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O
InChI
1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H
InChIKey
BLMPQMFVWMYDKT-NZTKNTHTSA-N
Safety Phrases
Classification:
Not WHMIS controlled.
Hazard statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
Carfilzomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-544)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19117922
Alternative Names
(αS)-α-2-(4-morpholinyl)acetylaminobenzenebutanoyl-L-leucyl-N-(1S)-3-methyl-1-(2R)-2-methyl-2-oxiranylcarbonylbutyl-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR
Research Areas
Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID
11556711
Scientific Background
Carfilzomib / PR-17 is an irreversible proteasome inhibitor that targets the chymotrypsin-like beta5 subunit of 20S proteasome. It can arrest the cell cycle and trigger apoptosis in tumor cell lines.
20S Proteasome inhibitor
Not WHMIS controlled.
Hazard statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.