Celastrol__Proteasome inhibitor Dorsomorphin (dihydrochloride)
Product Name
Celastrol
Description
Proteasome inhibitor
Purity
>98%
CAS No.
34157-83-0
Molecular Formula
C29H38O4
Molecular Weight
450.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
Source
Synthetic
Appearance
Red Powder
SMILES
CC1=C(C(=O)C=C2C1=CC=C3C@2(CCC@@4(C@@3(CCC@@5(email protected4CC@(CC5)(C)C(=O)O)C)C)C)C)O
InChI
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
Safety Phrases
Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H301 – Toxic if swallowed
Precautionary Statements:
P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
Cite This Product
Celastrol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-333)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19118589
Alternative Names
3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID
122724
Scientific Background
Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.
References
1. Sethi G., et al. (2007) Blood109: 2727.
2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.
3. Yang H., et al. (2006) Cancer Res. 66: 4758.
Proteasome inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H301 – Toxic if swallowed
Precautionary Statements:
P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.
3. Yang H., et al. (2006) Cancer Res. 66: 4758.