Chaetocin__Methyltransferase inhibitor A-443654
Product Name
Chaetocin
Description
Methyltransferase inhibitor
Purity
>99% (TLC), NMR conforms
CAS No.
28097-03-2
Molecular Formula
C30H28N6O6S4
Molecular Weight
696.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source
Synthetic
Appearance
Lyophilized Solid
InChI
InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40
InChIKey
PZPPOCZWRGNKIR-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Precautionary Statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Hazard Statements:
H302- Harmful if swallowed
H312- Harmful in contact with skin
H332- Harmful if inhaled
Cite This Product
Chaetocin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-351)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19118658
Alternative Names
2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino1',2':1,5pyrrolo2,3-bindole-1,1',4,4'-tetrone
Research Areas
Cancer, Cell Signaling, Epigenetics
PubChem ID
161591
Scientific Background
Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
References
1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143.
2. Isham, C.R., et al. (2007) Blood. 109: 2579.
Methyltransferase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Precautionary Statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Hazard Statements:
H302- Harmful if swallowed
H312- Harmful in contact with skin
H332- Harmful if inhaled
2. Isham, C.R., et al. (2007) Blood. 109: 2579.