Chloroquine diphosphate__Autophagy inhibitor Eleclazine (hydrochloride)
Product Name
Chloroquine diphosphate
Description
Autophagy inhibitor
Purity
>98%
CAS No.
50-63-5
Molecular Formula
C18H26ClN3·2H3PO4
Molecular Weight
515.86
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in water.
Source
Synthetic
Appearance
Beige Solid
SMILES
C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=P(O)(O)O.O=P(O)(O)O
InChI
InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChIKey
QKICWELGRMTQCR-UHFFFAOYSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Chloroquine diphosphate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-405)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19118816
Alternative Names
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Research Areas
Cancer, Autophagy
PubChem ID
64927
Scientific Background
Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.
References
1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14.
2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.
Autophagy inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.