Cyclopamine__Hedgehog signaling blocker Vanoxerine
Product Name
Cyclopamine
Description
Hedgehog signaling blocker
Purity
>98%
CAS No.
4449-51-8
Molecular Formula
C27H41NO2
Molecular Weight
434.15
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 5 mM in ethanol
Source
Synthetic
Appearance
White Solid
SMILES
Cemail protected1CC@@H2email protected(email protected(C@3(O2)CCemail protected4C@@H5CC=C6Cemail protected(CCC@@6(email protected5CC4=C3C)C)O)C)NC1
InChI
InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17
InChIKey
QASFUMOKHFSJGL-LAFRSMQTSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Cite This Product
Cyclopamine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-226)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120058
Alternative Names
(3β,22S,23R)-17,23-Epoxyveratraman-3-ol
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Hedgehog Pathway Blocker
PubChem ID
442972
Scientific Background
Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2).
References
1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009.
2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574.
Hedgehog signaling blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574.