Cyclosporine__Immunosuppressant CUDC-907
Product Name
Cyclosporine
Description
Immunosuppressant
Purity
>99%
CAS No.
59865-13-3
Molecular Formula
C62H111N11O12
Molecular Weight
1202.63
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO, 50 mM in ethanol
Source
Synthetic
Appearance
White Solid
SMILES
CCemail protected1C(=O)N(CC(=O)N(email protected(C(=O)Nemail protected(C(=O)N(email protected(C(=O)Nemail protected(C(=O)NC@@H(C(=O)N(email protected(C(=O)N(email protected(C(=O)N(email protected(C(=O)N(email protected(C(=O)N1)C@@H(email protected(C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(
InChI
InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(
InChIKey
PMATZTZNYRCHOR-IMVLJIQESA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R45 – May cause cancer
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
Cite This Product
Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120072
Alternative Names
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
Research Areas
Cancer, Apoptosis
PubChem ID
5284373
Scientific Background
Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
References
1. Heitman J., et al. (1992) New Biol. 4:448.
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
Immunosuppressant
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R45 – May cause cancer
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.