Cytochalasin D__Actin polymerization inhibitor SCH772984
Product Name
Cytochalasin D
Description
Actin polymerization inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
22144-77-0
Molecular Formula
C30H37NO6
Molecular Weight
507.63
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
Cemail protected1C/C=C/email protected2C@@H(C(=C)email protected(C@@H3C@@2(C@@H(/C=C/email protected(C1)C)OC(=O)C)C(=O)Nemail protected3CC4=CC=CC=C4)C)O
InChI
InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,3
InChIKey
SDZRWUKZFQQKKV-BBXOWAOSSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H300-H361
Precautionary Phrases:
P264-P281-P301 + P310
Cite This Product
Cytochalasin D (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-241)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120088
Alternative Names
(3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR)-3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundecadisoindol-15-yl acetate, Zygosporin A
Research Areas
Cancer, Apoptosis
PubChem ID
5458428
Scientific Background
Cytochalasins have the ability to bind to actin filaments and block polymerization and elongation of actin. As a result, they can change cellular morphology, inhibit cellular processes and cause cells to undergo apoptosis (1). Cytochalasin D in particular can inhibit protein synthesis (2).
References
1. Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053.
2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.
Actin polymerization inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 – Possible risk of impaired fertility
R68 – Possible risk of irreversible effects
Hazard Phrases:
H300-H361
Precautionary Phrases:
P264-P281-P301 + P310
2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.