DAPT__γ-secretase inhibitor SCH 527123
Product Name
DAPT
Description
γ-secretase inhibitor
Purity
>99%
CAS No.
208255-80-5
Molecular Formula
C23H26F2N2O4
Molecular Weight
432.46
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White to off-white powder
SMILES
email protected(NC(=O)C@@H(NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O
InChI
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120266
Alternative Names
N-(3,5-Difluorophenyl)acetyl-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester
Research Areas
Cell Signaling, Neuroscience
PubChem ID
5311272
Scientific Background
Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
References
1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81.
2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.
3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.
γ-secretase inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.
3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.