DBeQ__p97 inhibitor Fexaramine
Product Name
DBeQ
Description
p97 inhibitor
Purity
>98%
Molecular Formula
C22H20N4
Molecular Weight
340.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO
Source
Synthetic
Appearance
Yellow Powder
SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
InChI
InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChIKey
QAIMUUJJAJBPCL-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic Material Causing other toxic effects- moderate eye irritant.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
Precautionary Statements:
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product
DBeQ (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-334)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120276
Alternative Names
N,N'-Dibenzyl-2,4-quinazolinediamine, JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine, N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Research Areas
Cancer, Apoptosis
PubChem ID
676352
Scientific Background
A potent, selective and reversible inhibitor of the AAA-ATP p97 (ATPase associated with diverse cellular activities). Ki=3.2 M. It blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
References
1. Chou T.F., et al. 2011 PNAS 108:4834.
p97 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
Precautionary Statements:
P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.