Dasatinib__Kinase inhibitor KB-R7943 (mesylate)
Product Name
Dasatinib
Description
Kinase inhibitor
Purity
>98%
CAS No.
302962-49-8
Molecular Formula
C22H26ClN7O2S
Molecular Weight
488.0
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly )
Source
Synthetic
Appearance
Crystalline solid
SMILES
C1=C(SC(=N1)NC2=CC(=NC(=N2)C)N3CCN(CC3)CCO)C(=O)NC4=C(C=CC=C4Cl)C
InChI
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey
ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute Toxicity: Oral, Category 3
Toxic To Reproduction, Category 1B
Target Organ Systemic Toxicity (single exposure), Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301: Toxic if swallowed.
H360: May damage fertility or the unborn child.
H370: Causes damage to organs {uterus, testicles,ovaries}.
H373: May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure.
Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
P314: Get medical attentiodvice if you feel unwell.
Cite This Product
Dasatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-440)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120272
Alternative Names
N-(2-chloro-6-methylphenyl)-2-6-4-(2-hydroxyethyl)piperazin-1-yl-2-methylpyrimidin-4-ylamino-1,3-thiazole-5-carboxamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
3062316
Scientific Background
Dasatinib is a dual Src and Abl kinase inhibitor with ∼325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.
References
1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287.
Kinase inhibitor
Acute Toxicity: Oral, Category 3
Toxic To Reproduction, Category 1B
Target Organ Systemic Toxicity (single exposure), Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301: Toxic if swallowed.
H360: May damage fertility or the unborn child.
H370: Causes damage to organs {uterus, testicles,ovaries}.
H373: May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure.
Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P260: Do not breathe {dust/fume/gas/mist/vapours/spray}.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
P308+313: IF exposed or concerned: Get medical attentiodvice.
P312: Call a {POISON CENTER/doctor/…} if you feel unwell.
P314: Get medical attentiodvice if you feel unwell.