Decitabine__DNA hypomethylation agent Iguratimod
Product Name
Decitabine
Description
DNA hypomethylation agent
Purity
>98% (TLC); NMR (Conforms)
CAS No.
2353-33-5
Molecular Formula
C8H12N4O4
Molecular Weight
228.2
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol
Source
Synthetic
Appearance
White Solid
SMILES
C1C@@H(email protected(Oemail protected1N2C=NC(=NC2=O)N)CO)O
InChI
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChIKey
XAUDJQYHKZQPEU-KVQBGUIXSA-N
Safety Phrases
Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341 – Suspected of causing genetic defects
H360 – May damage fertility or the unborn child
Precautionary Statements:
P280 – Wear protective gloves/protective clothing/ eye protection/ face protection
P308+313 – If exposed or concerned: Get Medical Advise/Attention
Cite This Product
Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120312
Alternative Names
5-Aza-2’-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Research Areas
Cancer, Cell Signaling, Epigenetics
PubChem ID
451668
Scientific Background
Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.
References
1. Bender C.M., et al. (1998) Cancer Res. 58: 95.
2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.
DNA hypomethylation agent
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341 – Suspected of causing genetic defects
H360 – May damage fertility or the unborn child
Precautionary Statements:
P280 – Wear protective gloves/protective clothing/ eye protection/ face protection
P308+313 – If exposed or concerned: Get Medical Advise/Attention
2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.