Deguelin__Akt inhibitor GW 4064
Product Name
Deguelin
Description
Akt inhibitor
Purity
>98%
CAS No.
522-17-8
Molecular Formula
C23H22O6
Molecular Weight
394.42
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Source
Synthetic
Appearance
Cream Solid
SMILES
CC1(C=CC2=C(O1)C=CC3=C2OC@@H4COC5=CC(=C(C=C5C@@H4C3=O)OC)OC)C
InChI
InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H
InChIKey
ORDAZKGHSNRHTD-UXHICEINSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Deguelin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-251)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120321
Alternative Names
(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno3,4-bpyrano2,3-hchromen-7(7aH)-one
Research Areas
Cancer, Apoptosis
PubChem ID
107935
Scientific Background
Deguelin is a rotenoid, and a naturally occurring insecticide. Deguelin displays anti-cancer activity by inhibiting the growth of pre-cancerous and cancerous cells (1). High doses may have negative effects on the heart, lungs and nerves however. Deguelin has also been shown to have a correlation with Parkinson’s disease in rats (2).
References
1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124.
2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.
Akt inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.