Dexamethasone__Glucocorticoid receptor ligand Maytansinol
Product Name
Dexamethasone
Description
Glucocorticoid receptor ligand
Purity
>98%
CAS No.
50-02-2
Molecular Formula
C22H29FO5
Molecular Weight
392.47
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
CC@@H1Cemail protected2C@@H3CCC4=CC(=O)C=CC@@4(C@3(email protected(CC@@2(C@1(C(=O)CO)O)C)O)F)C
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,2
InChIKey
UREBDLICKHMUKA-CXSFZGCWSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 – Possible risk of impaired fertility
R68- Possible risk of irreversible effects
Hazard Phrases:
H315-H317-H319-H334-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338-P342 + P311
Cite This Product
Dexamethasone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-259)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120339
Alternative Names
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Research Areas
Cancer, Apoptosis
PubChem ID
5743
Scientific Background
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It is an anti-inflammatory and immunosuppressant. In cancer patients, it can be give to augment the antiemetic effect of 5-HT3 receptor antagonists, and is also used to counteract the development of edema (1). In a diagnostic setting, it is used to suppress the natural pituitary-adrenal axis (2).
References
1. Roila F., and Fatigoni S. (2006) Ann Oncol.17 (Suppl2): ii96-ii100.
2. Hasan E.A., Jessop D.S., Power L.L. Monk P.T. and Kirwan J.R. (2009) Int J Endocrinol. 2009: 391284.
Glucocorticoid receptor ligand
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62 – Possible risk of impaired fertility
R68- Possible risk of irreversible effects
Hazard Phrases:
H315-H317-H319-H334-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338-P342 + P311
2. Hasan E.A., Jessop D.S., Power L.L. Monk P.T. and Kirwan J.R. (2009) Int J Endocrinol. 2009: 391284.