Difluoromethylornithine__ODC Inhibitor LDK378
Product Name
Difluoromethylornithine
Description
ODC Inhibitor
Purity
>98%
CAS No.
70052-12-9
Molecular Formula
C6H12F2N2O2•HCl
Molecular Weight
218.63
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 75 mM in water
Source
Synthetic
Appearance
White Solid
SMILES
FC(F)NC(CCCN)C(O)=O
InChI
InChI=1S/C6H12F2N2O2/c7-6(8)10-4(5(11)12)2-1-3-9/h4,6,10H,1-3,9H2,(H,11,12)/t4-/m0/s1
InChIKey
LDLGBNXSBZFATB-BYPYZUCNSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Difluoromethylornithine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-200)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120488
Alternative Names
N2-(Difluoromethyl)ornithine, DFMO, Eflornithine
Research Areas
Cancer, Apoptosis
PubChem ID
3009
Scientific Background
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays anti-apoptotic, anti-angiogenic and anti-parasitic activity.
References
1. Malhotra B., Noveck R., Behr D., Palmisano M. (2001) J Clin Pharmacol. 41: 972-978.
ODC Inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection