Dihydroceramide__Autophagy inducer Calcitriol
Product Name
Dihydroceramide
Description
Autophagy inducer
Purity
>98%
CAS No.
13031-64-6
Molecular Formula
C20H41NO3
Molecular Weight
343.54
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in ethanol (5 mg/ml) or DMSO (5 mg/ml: dissolve in hot DMSO, then cool to RT).
Source
Synthetic
Appearance
White solid.
SMILES
C@@H(NC(=O)C)(email protected(O)CCCCCCCCCCCCCCC)CO
InChI
InChI=1S/C20H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h19-20,22,24H,3-17H2,1-2H3,(H,21,23)/t19-,20+/m0/s1
InChIKey
CRJGESKKUOMBCT-VQTJNVASSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Dihydroceramide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-398)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120500
Alternative Names
C2 Dihydroceramide, D-erythro-N-Acetylsphinganine
Research Areas
Cancer, Autophagy
PubChem ID
6610273
Scientific Background
Both in yeast and mammalian systems, dihydroceramide is the reaction intermediate found immediately prior to the final reaction product in the de novo synthesis of ceramide lipids. Recent studies have revealed that an accumulation of dihydroceramide will induce autophagy. Accumulation of dihydroceramide occurs due to inhibition of dihydroceramide desaturase, the enzyme responsible for the conversion of dihydroceramide into ceramide.
References
1. Gagliostro, V. et al. (2012). Int J Biochem Cell Biol, 44(12): 2135-43.
2. Jiang, Q. et al. (2012). Int J Cancer, 130(3): 685-93.
3. Signorelli, P. et al. (2009). Cancer Lett, 282(2): 238-43.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Jiang, Q. et al. (2012). Int J Cancer, 130(3): 685-93.
3. Signorelli, P. et al. (2009). Cancer Lett, 282(2): 238-43.