Dimethyloxaloylglycine (DMOG)__Prolyl-4-hydroxylase inhibitor Otamixaban
Product Name
Dimethyloxaloylglycine (DMOG)
Description
Prolyl-4-hydroxylase inhibitor
Purity
>99%
CAS No.
89464-63-1
Molecular Formula
C6H9NO5
Molecular Weight
175.1
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml)
Source
Synthetic
Appearance
Off-white solid
SMILES
C(C(=O)OC)NC(C(=O)OC)=O
InChI
InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChIKey
BNJOZDZCRHCODO-UHFFFAOYSA-N
Safety Phrases
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
Cite This Product
Dimethyloxaloylglycine (DMOG) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-382)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19120509
Alternative Names
DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester
Research Areas
Cell Signaling
PubChem ID
560326
Scientific Background
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
References
1. Grozinger C.M., et al. (2001) J. Biol. Chem. 276(42): 38837-43.
2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95.
3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71.
4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.
Prolyl-4-hydroxylase inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes
Hazard Statements:
H302 – Harmful if swallowed
2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95.
3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71.
4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.