Docetaxel

Docetaxel__Microtubule stabilizer A-1155463

Product Name	Docetaxel
Description	Microtubule stabilizer
Purity	>98%
CAS No.	114977-28-5
Molecular Formula	C43H53NO14
Molecular Weight	807.88

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 100 mM in DMSO, and to 100 mM in ethanol
Source	Synthetic
Appearance	White solid
SMILES	CC1=C2email protected(C(=O)C@@3(email protected(CC@@H4C@(email protected3C@@H(C@@(C2(C)C)(CC@@H1OC(=O)C@@H(email protected(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
InChI	InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)
InChIKey	ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	Docetaxel (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-240)

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121387

Alternative Names	(2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10-trihydroxy-13-{(2R,3S)-2-hydroxy-3-({(2-methyl-2-propanyl)oxycarbonyl}amino)-3-phenylpropanoyloxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Research Areas	Cancer, Apoptosis
PubChem ID	148124
Scientific Background	Docetaxel is a semi-synthetic analogue of paclitaxel differing at two positions in its chemical structure (1). It also binds and stabilizes microtubules which leads to cell cycle arrest and apoptosis (2).
References	1. Clarke S.J., and Rivory L.P. (1999) Clin Pharmacokinet. 36(2): 99-114. 2. Woodward E.J. and Twelves C. (2010) Curr. Clin Pharmacol. 5(3): 226-231.