Dofetilide__Herg channel blocker Eliglustat
Product Name
Dofetilide
Description
Herg channel blocker
Purity
>98%
CAS No.
115256-11-6
Molecular Formula
C19H27N3O5S2
Molecular Weight
441.56
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White Solid
SMILES
CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
InChI
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H
InChIKey
IXTMWRCNAAVVAI-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
S57 – Use appropriate containment to avoid environmental contamination
Risk Phrases:
R22 – Harmful if swallowed
R48 – Danger of serious damage to health by prolonged exposure
R51/53 – Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H319-H360
Precautionary Phrases:
P201-P305 + P351 + P338-P308 + P313
Cite This Product
Dofetilide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-311)
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19121406
Alternative Names
N-(4-{2-Methyl(2-{4-(methylsulfonyl)aminophenoxy}ethyl)aminoethyl}phenyl)methanesulfonamide, Tikosyn, UK 68798
Research Areas
Ion Channels, Neuroscience
PubChem ID
71329
Scientific Background
Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).
References
1. Lentz T.L., Hilleman D.E. (2000) Pharmacotherapy. 20(7): 776-786.
2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.
Herg channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S53 – Avoid exposure – obtain special instruction before use
S57 – Use appropriate containment to avoid environmental contamination
Risk Phrases:
R22 – Harmful if swallowed
R48 – Danger of serious damage to health by prolonged exposure
R51/53 – Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment
R61 – May cause harm to the unborn child
R62 – Possible risk of impaired fertility
Hazard Phrases:
H302-H319-H360
Precautionary Phrases:
P201-P305 + P351 + P338-P308 + P313
2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.